Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species.
Identifieur interne : 002124 ( Main/Exploration ); précédent : 002123; suivant : 002125Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species.
Auteurs : Saskia L. Smits [Pays-Bas] ; Judith M A. Van Den Brand ; Anna De Lang ; Lonneke M E. Leijten ; Wilfred F. Van Ijcken ; Geert Van Amerongen ; Albert D M E. Osterhaus ; Arno C. Andeweg ; Bart L. HaagmansSource :
- Journal of virology [ 1098-5514 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Appareil respiratoire (virologie), Charge virale, Cytokines (métabolisme), Lésion pulmonaire aigüe (anatomopathologie), Macaca fascicularis, Maladies des primates (anatomopathologie), Maladies des primates (virologie), Poumon (anatomopathologie), Poumon (immunologie), Syndrome de détresse respiratoire de l'adulte (anatomopathologie), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (pathogénicité).
- MESH :
- anatomopathologie : Lésion pulmonaire aigüe, Maladies des primates, Poumon, Syndrome de détresse respiratoire de l'adulte, Syndrome respiratoire aigu sévère.
- immunologie : Poumon.
- métabolisme : Cytokines.
- pathogénicité : Virus du SRAS.
- virologie : Appareil respiratoire, Maladies des primates, Syndrome respiratoire aigu sévère.
- Animaux, Charge virale, Macaca fascicularis.
English descriptors
- KwdEn :
- Acute Lung Injury (pathology), Animals, Chlorocebus aethiops, Cytokines (metabolism), Lung (immunology), Lung (pathology), Macaca fascicularis, Primate Diseases (pathology), Primate Diseases (virology), Respiratory Distress Syndrome, Adult (pathology), Respiratory System (virology), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Viral Load.
- MESH :
- chemical , metabolism : Cytokines.
- immunology : Lung.
- pathogenicity : SARS Virus.
- pathology : Acute Lung Injury, Lung, Primate Diseases, Respiratory Distress Syndrome, Adult, Severe Acute Respiratory Syndrome.
- virology : Primate Diseases, Respiratory System, Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Macaca fascicularis, Viral Load.
Abstract
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), caused by influenza A virus H5N1 and severe acute respiratory syndrome coronavirus (SARS-CoV), supposedly depend on activation of the oxidative-stress machinery that is coupled with innate immunity, resulting in a strong proinflammatory host response. Inflammatory cytokines, such as interleukin 1β (IL-1β), IL-8, and IL-6, play a major role in mediating and amplifying ALI/ARDS by stimulating chemotaxis and activation of neutrophils. To obtain further insight into the pathogenesis of SARS-CoV-associated ALI, we compared SARS-CoV infections in two different nonhuman primate species, cynomolgus macaques and African green monkeys. Viral titers in the upper and lower respiratory tract were not significantly different in SARS-CoV-infected macaques and African green monkeys. Inflammatory cytokines that play a major role in mediating and amplifying ALI/ARDS or have neutrophil chemoattractant activity, such as IL-6, IL-8, CXCL1, and CXCL2, were, however, induced only in macaques. In contrast, other proinflammatory cytokines and chemokines, including osteopontin and CCL3, were upregulated in the lungs of African green monkeys to a significantly greater extent than in macaques. Because African green monkeys developed more severe ALI than macaques, with hyaline membrane formation, some of these differentially expressed proinflammatory genes may be critically involved in development of the observed pathological changes. Induction of distinct proinflammatory genes after SARS-CoV infection in different nonhuman primate species needs to be taken into account when analyzing outcomes of intervention strategies in these species.
DOI: 10.1128/JVI.02395-10
PubMed: 21325418
Affiliations:
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Smits</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, Netherlands. s.smits@erasmusmc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam</wicri:regionArea><wicri:noRegion>3000 CA Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M A" last="Van Den Brand">Judith M A. Van Den Brand</name></author><author><name sortKey="De Lang, Anna" sort="De Lang, Anna" uniqKey="De Lang A" first="Anna" last="De Lang">Anna De Lang</name></author><author><name sortKey="Leijten, Lonneke M E" sort="Leijten, Lonneke M E" uniqKey="Leijten L" first="Lonneke M E" last="Leijten">Lonneke M E. Leijten</name></author><author><name sortKey="Van Ijcken, Wilfred F" sort="Van Ijcken, Wilfred F" uniqKey="Van Ijcken W" first="Wilfred F" last="Van Ijcken">Wilfred F. Van Ijcken</name></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name></author><author><name sortKey="Andeweg, Arno C" sort="Andeweg, Arno C" uniqKey="Andeweg A" first="Arno C" last="Andeweg">Arno C. Andeweg</name></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Lung Injury (pathology)</term><term>Animals</term><term>Chlorocebus aethiops</term><term>Cytokines (metabolism)</term><term>Lung (immunology)</term><term>Lung (pathology)</term><term>Macaca fascicularis</term><term>Primate Diseases (pathology)</term><term>Primate Diseases (virology)</term><term>Respiratory Distress Syndrome, Adult (pathology)</term><term>Respiratory System (virology)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Appareil respiratoire (virologie)</term><term>Charge virale</term><term>Cytokines (métabolisme)</term><term>Lésion pulmonaire aigüe (anatomopathologie)</term><term>Macaca fascicularis</term><term>Maladies des primates (anatomopathologie)</term><term>Maladies des primates (virologie)</term><term>Poumon (anatomopathologie)</term><term>Poumon (immunologie)</term><term>Syndrome de détresse respiratoire de l'adulte (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lésion pulmonaire aigüe</term><term>Maladies des primates</term><term>Poumon</term><term>Syndrome de détresse respiratoire de l'adulte</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Acute Lung Injury</term><term>Lung</term><term>Primate Diseases</term><term>Respiratory Distress Syndrome, Adult</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Maladies des primates</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Primate Diseases</term><term>Respiratory System</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Macaca fascicularis</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Charge virale</term><term>Macaca fascicularis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), caused by influenza A virus H5N1 and severe acute respiratory syndrome coronavirus (SARS-CoV), supposedly depend on activation of the oxidative-stress machinery that is coupled with innate immunity, resulting in a strong proinflammatory host response. Inflammatory cytokines, such as interleukin 1β (IL-1β), IL-8, and IL-6, play a major role in mediating and amplifying ALI/ARDS by stimulating chemotaxis and activation of neutrophils. To obtain further insight into the pathogenesis of SARS-CoV-associated ALI, we compared SARS-CoV infections in two different nonhuman primate species, cynomolgus macaques and African green monkeys. Viral titers in the upper and lower respiratory tract were not significantly different in SARS-CoV-infected macaques and African green monkeys. Inflammatory cytokines that play a major role in mediating and amplifying ALI/ARDS or have neutrophil chemoattractant activity, such as IL-6, IL-8, CXCL1, and CXCL2, were, however, induced only in macaques. In contrast, other proinflammatory cytokines and chemokines, including osteopontin and CCL3, were upregulated in the lungs of African green monkeys to a significantly greater extent than in macaques. Because African green monkeys developed more severe ALI than macaques, with hyaline membrane formation, some of these differentially expressed proinflammatory genes may be critically involved in development of the observed pathological changes. Induction of distinct proinflammatory genes after SARS-CoV infection in different nonhuman primate species needs to be taken into account when analyzing outcomes of intervention strategies in these species.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Andeweg, Arno C" sort="Andeweg, Arno C" uniqKey="Andeweg A" first="Arno C" last="Andeweg">Arno C. Andeweg</name><name sortKey="De Lang, Anna" sort="De Lang, Anna" uniqKey="De Lang A" first="Anna" last="De Lang">Anna De Lang</name><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><name sortKey="Leijten, Lonneke M E" sort="Leijten, Lonneke M E" uniqKey="Leijten L" first="Lonneke M E" last="Leijten">Lonneke M E. Leijten</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M A" last="Van Den Brand">Judith M A. Van Den Brand</name><name sortKey="Van Ijcken, Wilfred F" sort="Van Ijcken, Wilfred F" uniqKey="Van Ijcken W" first="Wilfred F" last="Van Ijcken">Wilfred F. Van Ijcken</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. 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